Protein Name:
Sodium-coupled neutral amino acid symporter 2
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UniprotKB/SwissProt ID: Q8CFE6 (Q8CFE6)
Gene Name:
Slc38a2
Organism: Mus musculus (Mouse)
Function: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:34406367). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (PubMed:16365304). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (PubMed:34406367)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR013057
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AA_transpt_TM |
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The S-nitrosylation sites of Q8CFE6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
400 |
PIRSSVTHLL C PTKEFSWLRH |
CCCCCCCCCC C CCCCCCCCCC |
5.17% |
20925432
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