UniprotKB/SwissProt ID: Q8CBX0 (Q8CBX0)
Gene Name:
Tmem63c
Organism: Mus musculus (Mouse)
Function: Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:27045885, PubMed:32375046, PubMed:37945568). In contrast to TMEM63B, does not show phospholipid scramblase activity (By similarity). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (By similarity). In particular may regulate mitochondrial motility and function in motor neuron axons (By similarity). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Cell membrane
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