UniprotKB/SwissProt ID: Q8C1E7 (Q8C1E7)
Gene Name:
Tmem120a
Organism: Mus musculus (Mouse)
Function: Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation (PubMed:26024229, PubMed:32084332, PubMed:34731626, PubMed:35027552, PubMed:39147733). May function as a potential ion channel involved in sensing mechanical stimuli (By similarity). Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (By similarity). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (PubMed:35819364, PubMed:39147733). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism (PubMed:34374644)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Nucleus envelope. Nucleus inner membrane. Endoplasmic reticulum
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