UniprotKB/SwissProt ID: Q8C165 (Q8C165)
Gene Name:
Pm20d1
Organism: Mus musculus (Mouse)
Function: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (Probable) (PubMed:27374330, PubMed:29533650, PubMed:29967167, PubMed:32271712, PubMed:32402239). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure (PubMed:27374330, PubMed:29967167, PubMed:32271712). PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (PubMed:32402239)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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