Protein Name:
Zinc transporter ZIP6
|
UniprotKB/SwissProt ID: Q8C145 (Q8C145)
Gene Name:
Slc39a6
Organism: Mus musculus (Mouse)
Function: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:28098160). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (By similarity). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (PubMed:28098160). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as E-cadherin, causing loss of cell adherence (By similarity). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (By similarity). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, lamellipodium membrane. Membrane raft. Apical cell membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q8C145
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
153 |
VAGKNNRKAF C PDLDSDNSGK |
|
|
|
| 2 |
312 |
AIINQIDARA C LIHTASEKKA |
|
|
|
|
