Protein Name:
Calcium/calmodulin-dependent protein kinase kinase 2
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UniprotKB/SwissProt ID: Q8C078 (Q8C078)
Gene Name:
Camkk2
Organism: Mus musculus (Mouse)
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching (By similarity). May be involved in hippocampal activation of CREB1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cell projection, neuron projection
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8C078
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
548 |
RQPPGPRAGP C GGGGSALVKG |
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