UniprotKB/SwissProt ID: Q8BYK4 (Q8BYK4)
Gene Name:
Rdh12
Organism: Mus musculus (Mouse)
Function: Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity toward 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (By similarity). Plays an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:17032653, PubMed:19686838, PubMed:22621924). Has no dehydrogenase activity towards steroids (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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