Protein Name:
Histone acetyltransferase type B catalytic subunit
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UniprotKB/SwissProt ID: Q8BY71 (Q8BY71)
Gene Name:
Hat1
Organism: Mus musculus (Mouse)
Function: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:23754951). Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation (PubMed:23754951). Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23754951). In addition, acetylates other substrates such as chromatin-related proteins. Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus matrix. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BY71
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
24 |
AVEKKLAEYK C NTNTAIELKL |
CCHHHHHHHH H HHHHHHHHHH |
8.11% |
20925432
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