UniprotKB/SwissProt ID: Q8BXK9 (Q8BXK9)
Gene Name:
Clic5
Organism: Mus musculus (Mouse)
Function: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (By similarity). Required for normal hearing (By similarity). Necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (PubMed:17021174, PubMed:24285636). Required for the proper localization of PTPRQ and RDX to the stereocilium base during postnatal maturation of hair bundles (PubMed:24285636). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions (By similarity). Required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (PubMed:29425878)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Membrane. Apical cell membrane. Cytoplasm. Mitochondrion. Cell projection, stereocilium
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