Protein Name:
Intraflagellar transport protein 57 homolog
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UniprotKB/SwissProt ID: Q8BXG3 (Q8BXG3)
Gene Name:
Ift57
Organism: Mus musculus (Mouse)
Function: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR019530
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Intra-flagellar_transport_57 |
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The S-nitrosylation sites of Q8BXG3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
410 |
TLLQSKLKEK C NMTRDMHAAV |
CCCCCEECCC C CCCCCCCCCC |
4.4% |
21278135
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