Protein Name:
Eukaryotic peptide chain release factor subunit 1
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UniprotKB/SwissProt ID: Q8BWY3 (Q8BWY3)
Gene Name:
Etf1
Organism: Mus musculus (Mouse)
Function: Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site, followed by hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BWY3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
127 |
FKPINTSLYL C DNKFHTEALT |
CCCCCCHHHH C HHHHHHHHHH |
3.24% |
20925432
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| 2 |
335 |
NLDIMRYVLH C QGTEEEKILY |
CCCCCCHHHH C HHHHHHHHHH |
3.31% |
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