Protein Name:
3-ketoacyl-CoA thiolase, mitochondrial
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UniprotKB/SwissProt ID: Q8BWT1 (Q8BWT1)
Gene Name:
Acaa2
Organism: Mus musculus (Mouse)
Function: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BWT1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
103 |
GSGFQSIVSG C QEICSKDAEV |
CCHHCCEEEE E EECCCCCCCC |
2.27% |
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| 2 |
107 |
QSIVSGCQEI C SKDAEVVLCG |
CCHHCCEEEE E EECCCCCCCC |
3.99% |
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| 3 |
116 |
ICSKDAEVVL C GGTESMSQSP |
CCHHCCEEEE E EECCCCCCCC |
2.97% |
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| 4 |
128 |
GTESMSQSPY C VRNVRFGTKF |
CCHHCCEEEE E EECCCCCCCC |
2.35% |
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| 5 |
179 |
AAKYNISRED C DRYALQSQQR |
CCHHCCEEEE E EECCCCCCCC |
2.48% |
22178444
21278135
23748021
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| 6 |
287 |
ARVVGYFVSG C DPTIMGIGPV |
CCHHCCEEEE E EECCCCCCCC |
4.39% |
22178444
21278135
23748021
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| 7 |
382 |
RGGKYAVGSA C IGGGQGIALI |
CCHHCCEEEE E EECCCCCCCC |
2.96% |
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| 8 |
92 |
ETGALTLNRL C GSGFQSIVSG |
CCHHCCEEEE E EECCCCCCCC |
3.53% |
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