Protein Name:
Phosducin-like protein 3
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UniprotKB/SwissProt ID: Q8BVF2 (Q8BVF2)
Gene Name:
Pdcl3
Organism: Mus musculus (Mouse)
Function: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BVF2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
128 |
LHLYKQGIPL C SLINHHLSGL |
CCCCCCCCCH H HHHHHCCCCC |
2.33% |
20925432
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| 2 |
155 |
VKFIKAISTT C IPNYPDRNLP |
CCCCCCCCCH H HHHHHCCCCC |
5.02% |
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