Protein Name:
Lipid droplet-associated hydrolase
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UniprotKB/SwissProt ID: Q8BVA5 (Q8BVA5)
Gene Name:
Ldah
Organism: Mus musculus (Mouse)
Function: Probable serine lipid hydrolase associated with lipid droplets (PubMed:24357060, PubMed:28578400). Has low cholesterol esterase activity (PubMed:24357060, PubMed:27836991). Appears to lack triglyceride lipase activity (PubMed:23525007, PubMed:24357060, PubMed:27836991). Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (PubMed:24357060) Stimulates cellular triglyceride accumulation and lipid droplet fusion Associates with lipid droplets but does not stimulate cellular triglyceride accumulation, lipid droplet fusion or ATGL proteasomal degradation Stimulates cellular triglyceride accumulation and lipid droplet fusion
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lipid droplet. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BVA5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
185 |
PNGKFATPFL C QFRYLLYATS |
CCCCHHHCCC C CCEEEECCCE |
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21278135
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