UniprotKB/SwissProt ID: Q8BUE4 (Q8BUE4)
Gene Name:
Aifm2
Organism: Mus musculus (Mouse)
Function: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis (By similarity). At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis (By similarity). Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis (By similarity). This anti-ferroptotic function is independent of cellular glutathione levels (By similarity). Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms (PubMed:35922516). Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis (PubMed:26689472). May play a role in mitochondrial stress signaling (PubMed:26689472). Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lipid droplet. Cell membrane. Cytoplasm. Mitochondrion membrane. Nucleus
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