Protein Name:
Mitochondrial tRNA methylthiotransferase CDK5RAP1
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UniprotKB/SwissProt ID: Q8BTW8 (Q8BTW8)
Gene Name:
Cdk5rap1
Organism: Mus musculus (Mouse)
Function: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:25738458). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:25738458). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (PubMed:25738458)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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