Protein Name:
Importin-5
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UniprotKB/SwissProt ID: Q8BKC5 (Q8BKC5)
Gene Name:
Ipo5
Organism: Mus musculus (Mouse)
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (PubMed:22730302)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BKC5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
110 |
ETQSSMRKKI C DIAAELARNL |
CCHHHHHHHH H HHHHHHCCCC |
4.2% |
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| 2 |
266 |
EATLQLSLKL C GDTNLNNMQR |
CCHHHHHHHH H HHHHHHCCCC |
4.42% |
21278135
|
| 3 |
420 |
DPHPRVRYAA C NAVGQMATDF |
CCHHHHHHHH H HHHHHHCCCC |
2.27% |
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| 4 |
682 |
TAGLEEKSTA C QMLVCYAKEL |
CCHHHHHHHH H HHHHHHCCCC |
2.18% |
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| 5 |
733 |
AAESMPLLLE C ARVRGPEYLT |
CCHHHHHHHH H HHHHHHCCCC |
2.71% |
21278135
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| 6 |
972 |
TKENVNATEN C ISAVGKIMKF |
CCHHHHHHHH H HHHHHHCCCC |
1.8% |
21278135
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