Protein Name:
RUN and FYVE domain-containing protein 1
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UniprotKB/SwissProt ID: Q8BIJ7 (Q8BIJ7)
Gene Name:
Rufy1
Organism: Mus musculus (Mouse)
Function: Activating adapter involved in cargo sorting from early/recycling endosomes (PubMed:11172003, PubMed:16522682). Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex. Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (By similarity). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:11509568). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (PubMed:38382525)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BIJ7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
188 |
FGPLELVEKL C PEASDIATSV |
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