UniprotKB/SwissProt ID: Q8BHY3 (Q8BHY3)
Gene Name:
Ano1
Organism: Mus musculus (Mouse)
Function: Calcium-activated chloride channel (CaCC) (PubMed:18724360, PubMed:22002868, PubMed:22634729, PubMed:23840801, PubMed:24913262, PubMed:25779870, PubMed:28561733, PubMed:28963502, PubMed:29236684, PubMed:29236691, PubMed:31147466, PubMed:34089532, PubMed:34433575, PubMed:35135993). Plays a role in transepithelial anion transport and smooth muscle contraction (PubMed:28561733, PubMed:29236684, PubMed:29236691). Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (By similarity). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (PubMed:30586313). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (By similarity). However, was shown in another study not to be required for MUC5AC expression (By similarity). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (PubMed:35129434). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (PubMed:34433575). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (PubMed:34089532). Acts as a heat sensor in nociceptive neurons (PubMed:22634729). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (PubMed:35135993). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (PubMed:31147466)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Presynapse
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