UniprotKB/SwissProt ID: Q8BHG1 (Q8BHG1)
Gene Name:
Nrdc
Organism: Mus musculus (Mouse)
Function: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination (PubMed:19935654). Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (PubMed:28017472)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cell projection, dendrite
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