Protein Name:
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
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UniprotKB/SwissProt ID: Q8BH59 (Q8BH59)
Gene Name:
Slc25a12
Organism: Mus musculus (Mouse)
Function: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BH59
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
375 |
GELMYKNSFD C FKKVLRYEGF |
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21278135
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| 2 |
435 |
PLPAEILAGG C AGGSQVIFTN |
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21278135
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| 3 |
487 |
LFGLYKGAKA C FLRDIPFSAI |
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21278135
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| 4 |
563 |
GQTTYSGVVD C FRKILREEGP |
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21278135
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