Protein Name:
Eukaryotic translation initiation factor 5A-2
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UniprotKB/SwissProt ID: Q8BGY2 (Q8BGY2)
Gene Name:
Eif5a2
Organism: Mus musculus (Mouse)
Function: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q8BGY2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
38 |
NGFVVLKGRP C KIVEMSTSKT |
CCCCCEECCC C CCCCCCCCCC |
4.53% |
21278135
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| 2 |
73 |
IFTGKKYEDI C PSTHNMDVPN |
CCCCCEECCC C CCCCCCCCCC |
3.17% |
24926564
21278135
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