UniprotKB/SwissProt ID: Q8BGD5 (Q8BGD5)
Gene Name:
Cpt1c
Organism: Mus musculus (Mouse)
Function: Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (By similarity). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (PubMed:32931550). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524, PubMed:22539351, PubMed:37309891). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:12376098, PubMed:25751282, PubMed:30135643)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Synapse. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Endoplasmic reticulum membrane
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