Protein Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
|
UniprotKB/SwissProt ID: Q8BFP9 (Q8BFP9)
Gene Name:
Pdk1
Organism: Mus musculus (Mouse)
Function: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q8BFP9
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
419 |
YKANHEADDW C VPSREPKDMT |
CCHHHHHCCC C CCCCEECCCC |
4.08% |
21278135
|
| 2 |
71 |
QFLDFGSVNA C EKTSFMFLRQ |
CCHHHHHCCC C CCCCEECCCC |
4.68% |
21278135
|
|
