Protein Name:
Inactive tyrosine-protein kinase PRAG1
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UniprotKB/SwissProt ID: Q86YV5 (Q86YV5)
Gene Name:
PRAG1
Organism: Homo sapiens (Human)
Function: Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell junction, focal adhesion. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86YV5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
311 |
EKRGPSFPKE C CSQGPTAHPS |
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| 2 |
312 |
KRGPSFPKEC C SQGPTAHPSC |
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| 3 |
322 |
CSQGPTAHPS C LGPKKLSLTS |
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| 4 |
382 |
PAPEKQQDPG C PGVTPSRCLG |
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| 5 |
446 |
AAAAQGQGQV C TGNAWAQKAA |
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| 6 |
612 |
NGVAISDPSR C PQPAASSASE |
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