Protein Name:
G-protein-signaling modulator 1
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UniprotKB/SwissProt ID: Q86YR5 (Q86YR5)
Gene Name:
GPSM1
Organism: Homo sapiens (Human)
Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86YR5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
497 |
IPRAPSSDEE C FFDLLTKFQS |
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| 2 |
515 |
FQSSRMDDQR C PLDDGQAGAA |
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| 3 |
670 |
AGGPPEPQQQ C QPGAS----- |
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