Protein Name:
Ankyrin repeat and LEM domain-containing protein 2
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UniprotKB/SwissProt ID: Q86XL3 (Q86XL3)
Gene Name:
ANKLE2
Organism: Homo sapiens (Human)
Function: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86XL3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
176 |
PEEEAVTSKT C SVPPSDTDTY |
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| 2 |
203 |
SKEPPLYYGV C PVYEDVPARN |
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| 3 |
286 |
FSNDRLKDGL C LSESETVNKE |
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| 4 |
350 |
GDNPTIVQEG C RYNVMHVAAK |
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| 5 |
454 |
KYDKTPEDVI C ERSKNKSVEL |
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| 6 |
674 |
PTVGAFGHTR C SAFPLEQEAD |
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