Protein Name:
Deaminated glutathione amidase
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UniprotKB/SwissProt ID: Q86X76 (Q86X76)
Gene Name:
NIT1
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86X76
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
251 |
LLRARAIETQ C YVVAAAQCGR |
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| 2 |
67 |
TPDKQQNFKT C AELVREAARL |
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| 3 |
80 |
LVREAARLGA C LAFLPEAFDF |
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