Protein Name:
Coiled-coil domain-containing protein 25
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UniprotKB/SwissProt ID: Q86WR0 (Q86WR0)
Gene Name:
CCDC25
Organism: Homo sapiens (Human)
Function: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endomembrane system
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86WR0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
150 |
RFPDLAAEKE C RDREERNEKK |
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| 2 |
83 |
HLVKANSIQG C KMNNVNVVYT |
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