Protein Name:
Rho guanine nucleotide exchange factor 25
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UniprotKB/SwissProt ID: Q86VW2 (Q86VW2)
Gene Name:
ARHGEF25
Organism: Homo sapiens (Human)
Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm, myofibril, sarcomere
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Graphical Visualization of S-nitrosylation Sites:
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