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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Thioredoxin reductase 3
UniprotKB/SwissProt ID: Q86VQ6 (Q86VQ6)

Gene Name: TXNRD3

Organism: Homo sapiens (Human)

Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR046952 GSHR/TRXR-like
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR036249 Thioredoxin-like_sf
IPR006338 Thioredoxin/glutathione_Rdtase
The S-nitrosylation sites of Q86VQ6
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 203 QGTSWGLGGT C VNVGCIPKKL   
2 208 GLGGTCVNVG C IPKKLMHQAA   
3 321 YLGIQGDKEY C ITSDDLFSLP