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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cullin-associated NEDD8-dissociated protein 1
UniprotKB/SwissProt ID: Q86VP6 (Q86VP6)

Gene Name: CAND1

Organism: Homo sapiens (Human)

Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
The S-nitrosylation sites of Q86VP6
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1007 PQPIDPLLKN C IGDFLKTLED  CCCHHHHHHH H HHHHCCCCCC  3.34% 22178444
2 1096 FECMYTLLDS C LDRLDIFEFL  CCCHHHHHHH H HHHHCCCCCC  4.59%
3 1134 FLMLVRLSTL C PSAVLQRLDR  CCCHHHHHHH H HHHHCCCCCC  2.25% 19483679
4 131 SSGSALAANV C KKITGRLTSA  CCCHHHHHHH H HHHHCCCCCC  3.59%
5 179 LVNFHPSILT C LLPQLTSPRL  CCCHHHHHHH H HHHHCCCCCC  3.09%
6 237 SMSTTRTYIQ C IAAISRQAGH  CCCHHHHHHH H HHHHCCCCCC  1.33%
7 264 EKIIPLVVKF C NVDDDELREY  CCCHHHHHHH H HHHHCCCCCC  3.93%
8 275 NVDDDELREY C IQAFESFVRR  CCCHHHHHHH H HHHHCCCCCC  1.27%
9 356 SWKVRRAAAK C LDAVVSTRHE  CCCHHHHHHH H HHHHCCCCCC  3.4% 37478858
10 571 ATPYIKDLFT C TIKRLKAADI  CCCHHHHHHH H HHHHCCCCCC  2.65% 19483679
11 71 NGEVQNLAVK C LGPLVSKVKE  CCCHHHHHHH H HHHHCCCCCC  4.22%
12 802 HKQSYYSIAK C VAALTRACPK  CCCHHHHHHH H HHHHCCCCCC  1.54%
13 954 EEGTRNVVAE C LGKLTLIDPE  CCCHHHHHHH H HHHHCCCCCC  4.35%