Protein Name:
Vacuolar protein-sorting-associated protein 36
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UniprotKB/SwissProt ID: Q86VN1 (Q86VN1)
Gene Name:
VPS36
Organism: Homo sapiens (Human)
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endosome. Late endosome. Membrane. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86VN1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
271 |
GGIMSLTEVY C LVNRARGMEL |
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| 2 |
291 |
LLSPEDLVNA C KMLEALKLPL |
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