Protein Name:
Reticulon-4 receptor-like 2
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UniprotKB/SwissProt ID: Q86UN3 (Q86UN3)
Gene Name:
RTN4RL2
Organism: Homo sapiens (Human)
Function: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane raft. Cell projection, dendrite. Perikaryon. Cell projection, axon
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86UN3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
141 |
ERLQSLHLYR C QLSSLPGNIF |
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