Protein Name:
Retrotransposon-derived protein PEG10
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UniprotKB/SwissProt ID: Q86TG7 (Q86TG7)
Gene Name:
PEG10
Organism: Homo sapiens (Human)
Function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Extracellular vesicle membrane. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q86TG7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
234 |
AKSLSALIGQ C IHIERRLARA |
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37478858
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| 2 |
308 |
CGTGGHYADN C PAKASKSSPA |
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| 3 |
597 |
RGWKLQVSYD C RAPNNFTIQN |
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| 4 |
78 |
AAPPPPIEEE C PEDLPEKFDG |
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