UniprotKB/SwissProt ID: Q811D0 (Q811D0)
Gene Name:
Dlg1
Organism: Mus musculus (Mouse)
Function: Essential multidomain scaffolding protein required for normal development (PubMed:11238884). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane. Endoplasmic reticulum membrane. Postsynaptic density. Synapse. Cell membrane, sarcolemma. Cell junction. Cytoplasm. Apical cell membrane
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