Protein Name:
Ras-related GTP-binding protein A
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UniprotKB/SwissProt ID: Q80X95 (Q80X95)
Gene Name:
Rraga
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:23263183). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:23263183). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:23263183). Involved in the RCC1/Ran-GTPase pathway (By similarity). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Lysosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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