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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Filamin-B

UniprotKB/SwissProt ID: Q80X90 (Q80X90)

Gene Name: Flnb

Organism: Mus musculus (Mouse)

Function: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001589 Actinin_actin-bd_CS
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR044801 Filamin
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

The S-nitrosylation sites of Q80X90

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1081 GGLGLTVEGP C EAKIECSDNG  CCCCHHHHHC C CCHHHHHHHH  13.44%
2 1155 HGKVGEPGIL C VDCSEAGPGT  CCCCHHHHHC C CCHHHHHHHH  1.98%
3 1280 ITNPSGASTE C FVKDNADGTY  CCCCHHHHHC C CCHHHHHHHH  4.87% 20925432
4 1326 SPFKVAVTEG C QPSRVHAQGP  CCCCHHHHHC C CCHHHHHHHH  4.35%
5 1434 VKIAGPGLSS C VRACIPQSFT  CCCCHHHHHC C CCHHHHHHHH  1.84% 20925432
6 1868 IEGPSKAEIS C IDNKDGTCTV  CCCCHHHHHC C CCHHHHHHHH  5.79% 20925432
7 2057 IQTEDLEDGT C KVSYFPTVPG  CCCCHHHHHC C CCHHHHHHHH  5.11% 20925432
8 2115 APAVATVGSI C DLNLKIPEIN  CCCCHHHHHC C CCHHHHHHHH  5.36% 20925432
9 2289 PVIAPSDDAR C LTVLSLQESG  CCCCHHHHHC C CCHHHHHHHH  3.91% 20925432
10 416 VEDRGNQVYR C VYKPVQPGPH  CCCCHHHHHC C CCHHHHHHHH  1.83%
11 604 IEYDDQNDGS C DVKYWPKEPG  CCCCHHHHHC C CCHHHHHHHH  9.48% 20925432
12 660 AYGPGLEKSG C TINNPAEFIV  CCCCHHHHHC C CCHHHHHHHH  4.45%
13 991 ILSPSRKVVP C LVAPVAGREC  CCCCHHHHHC C CCHHHHHHHH  3.01% 20925432