UniprotKB/SwissProt ID: Q80WM3 (Q80WM3)
Gene Name:
Cplx4
Organism: Mus musculus (Mouse)
Function: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896). Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Synapse. Cell membrane
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