Protein Name:
Reticulon-4 receptor-like 2
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UniprotKB/SwissProt ID: Q80WD1 (Q80WD1)
Gene Name:
Rtn4rl2
Organism: Rattus norvegicus (Rat)
Function: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (PubMed:15673660). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (By similarity). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, dendrite. Perikaryon. Cell projection, axon. Membrane raft
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Graphical Visualization of S-nitrosylation Sites:
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