Protein Name:
Protein VAC14 homolog
|
UniprotKB/SwissProt ID: Q80W92 (Q80W92)
Gene Name:
Vac14
Organism: Rattus norvegicus (Rat)
Function: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome membrane. Microsome membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q80W92
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
620 |
LKTLESQNLF C CLYRSWCHNP |
|
|
|
| 2 |
621 |
KTLESQNLFC C LYRSWCHNPV |
|
|
|
|
