Protein Name:
WD repeat domain phosphoinositide-interacting protein 2
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UniprotKB/SwissProt ID: Q80W47 (Q80W47)
Gene Name:
Wipi2
Organism: Mus musculus (Mouse)
Function: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:23051912, PubMed:23291478, PubMed:24954904). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (By similarity). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Preautophagosomal structure membrane
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Graphical Visualization of S-nitrosylation Sites:
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