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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: AP-4 complex subunit epsilon-1

UniprotKB/SwissProt ID: Q80V94 (Q80V94)

Gene Name: Ap4e1

Organism: Mus musculus (Mouse)

Function: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050840 Adaptor_Complx_Large_Subunit
IPR017109 AP4_complex_esu
IPR028269 AP4E1_C
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N

The S-nitrosylation sites of Q80V94

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 584 IQEFTVSLNT C LRQHAFELKH