Protein Name:
Membrane-associated progesterone receptor component 2
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UniprotKB/SwissProt ID: Q80UU9 (Q80UU9)
Gene Name:
Pgrmc2
Organism: Mus musculus (Mouse)
Function: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (PubMed:31748741)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Nucleus envelope. Endoplasmic reticulum. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q80UU9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
153 |
RDASRGLATF C LDKDALRDEY |
CCCCCCCEEE E ECCCCCCCCC |
4.11% |
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| 2 |
75 |
LWVRWGRRGL C SGPGAGEESP |
CCCCCCCEEE E ECCCCCCCCC |
5% |
21278135
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