Protein Name:
MAP kinase-activating death domain protein
|
UniprotKB/SwissProt ID: Q80U28 (Q80U28)
Gene Name:
Madd
Organism: Mus musculus (Mouse)
Function: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:11359932, PubMed:18559336). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (PubMed:11359932, PubMed:12388783, PubMed:18849981). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (PubMed:12388783). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (PubMed:18849981). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm. Cell projection, axon
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q80U28
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
763 |
RQTETGEGSV C QRTYDNPYFE |
|
|
|
|
