UniprotKB/SwissProt ID: Q80TS3 (Q80TS3)
Gene Name:
Adgrl3
Organism: Mus musculus (Mouse)
Function: Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:36244455, PubMed:38233523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:36244455, PubMed:36309016). ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context (PubMed:32778842, PubMed:36309016, PubMed:39798870). Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient (PubMed:32778842, PubMed:36244455). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity (PubMed:22405201, PubMed:25728924, PubMed:26235031, PubMed:30792275, PubMed:39798870). Specifically mediates the establishment of Schaffer-collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus (PubMed:30792275). Localizes to postsynaptic spines in excitatory synapses in the S.oriens and S.radiatum and interacts with presynaptic cell adhesion molecules FLRT3 and TENM2, promoting synapse formation (PubMed:30792275). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570) Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:38233523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:38233523). Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:38233523). Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation (PubMed:38233523) Orphan adhesion G-protein coupled receptor (aGPCR) (PubMed:38233523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:38233523). Isoform 7 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (PubMed:38233523)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Postsynaptic cell membrane. Cell projection, axon. Cell junction
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