Protein Name:
Wings apart-like protein homolog
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UniprotKB/SwissProt ID: Q7Z5K2 (Q7Z5K2)
Gene Name:
WAPL
Organism: Homo sapiens (Human)
Function: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus. Chromosome. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7Z5K2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
160 |
IVEDDASISS C NKLITSDKVE |
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| 2 |
251 |
NDFEDIRSED C ILSLDSDPLL |
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| 3 |
344 |
LNQAKKGGVS C GTSFRGTVGR |
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| 4 |
94 |
VSSKNLAQVK C SSYSESSEAA |
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| 5 |
964 |
QDGLIGTALN C VLQVPKYLPQ |
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