Protein Name:
BRCA1-associated protein
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UniprotKB/SwissProt ID: Q7Z569 (Q7Z569)
Gene Name:
BRAP
Organism: Homo sapiens (Human)
Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7Z569
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
234 |
RQFNSIEDDV C QLVYVERAEV |
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| 2 |
391 |
KTDGKIVQYE C EGDTCQEEKI |
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| 3 |
47 |
KKTTLASAVA C LEGKSPGEKV |
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