Protein Name:
COMM domain-containing protein 6
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UniprotKB/SwissProt ID: Q7Z4G1 (Q7Z4G1)
Gene Name:
COMMD6
Organism: Homo sapiens (Human)
Function: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:15799966, PubMed:16573520). Inhibits TNF-induced NFKB1 activation (PubMed:15799966, PubMed:16573520)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7Z4G1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
35 |
KLGMAVSSDT C RSLKYPYVAV |
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