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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: C-myc promoter-binding protein

UniprotKB/SwissProt ID: Q7Z401 (Q7Z401)

Gene Name: DENND4A

Organism: Homo sapiens (Human)

Function: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR043153 DENN_C
IPR051696 DENN_Domain_GEFs
IPR023341 MABP
IPR002885 Pentatricopeptide_rpt
IPR011990 TPR-like_helical_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The S-nitrosylation sites of Q7Z401

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1137 DSETDVSKAG C VATQNPKRIQ